You might think insulin resistance is just about blood sugar or weight gain—but your skin often knows long before you do. In fact, some of the most common skin concerns I see every day are actually early signs of insulin resistance. Let's break it down in a way that actually makes sense.

First—What Is Insulin Resistance? (Quick Version)

Insulin is a hormone that helps move sugar (glucose) from your bloodstream into your cells for energy.

When your body becomes resistant to insulin:

  • Your pancreas makes more and more insulin.
  • Your insulin levels stay high.
  • That excess insulin starts affecting almost every system in your body—including your skin.

1. Stubborn Acne (Especially Along the Jawline)

If your acne:

  • Shows up on your chin, jawline, or lower cheeks
  • Flares around your menstrual cycle
  • Doesn't respond to basic skincare

…it may not be a skin problem—it may be a hormone problem.

High insulin levels increase androgen hormones (such as testosterone), which can:

  • Increase oil production
  • Clog pores
  • Lead to deeper, cystic breakouts

2. Dark, Velvety Skin (Acanthosis Nigricans)

This is one of the most recognizable signs of insulin resistance.

Look for darkened, thickened skin on the:

  • Neck
  • Underarms
  • Groin
  • Other skin folds

This condition is called Acanthosis Nigricans.

High insulin levels stimulate skin cells to grow and thicken, meaning your skin is literally responding to metabolic stress.

3. Skin Tags (Especially on the Neck and Underarms)

Those tiny, soft, hanging growths?

They're called acrochordons (skin tags), and they're strongly associated with insulin resistance.

Common areas include:

  • Neck
  • Underarms
  • Under the breasts

They're not dangerous—but they can be an important clue.

4. Increased Oiliness and Larger Pores

  • Oil glands become overstimulated.
  • Skin becomes greasier.
  • Pores appear larger and more noticeable.

This often goes hand in hand with acne but can also occur on its own.

5. Slow Healing and Post-Inflammatory Dark Spots

If your skin:

  • Takes a long time to heal
  • Leaves behind dark marks after blemishes
  • Seems inflamed longer than it should

Insulin resistance may be affecting your body's ability to regulate inflammation and repair damaged skin.

So... What Should You Do About It?

Here's the part many people don't hear:

You can't out-skincare insulin resistance.

Improving your skin often means addressing what's happening inside your body, too.

A good place to start:

  • Prioritize protein and fiber at every meal.
  • Reduce added sugar and refined carbohydrates.
  • Incorporate strength training to improve insulin sensitivity.
  • Get consistent, quality sleep.
  • Talk with a healthcare provider if medical treatment may be appropriate.

When to Get Help

If you're noticing:

  • Persistent hormonal acne
  • Darkening of the neck or underarms
  • Multiple skin tags
  • Weight changes along with fatigue

…it may be worth getting evaluated.

These symptoms aren't just cosmetic—they can be early signs of metabolic health concerns.

The Wellwell Approach

At Wellwell, we look at both sides of the equation.

We address:

  • Skin treatment through personalized skincare and targeted therapies
  • Internal drivers like hormones, metabolism, and insulin resistance

Because treating one without the other is often why people continue to struggle with recurring skin concerns.

Lizzie Brennan

Author

Lizzie Brennan, PA-C is a board-certified Physician Assistant with more than 20 years of medical experience and over a decade specializing in dermatology. As the founder of WellWell, she combines expert skin care with evidence-based metabolic medicine to help patients feel confident inside and out. Lizzie is passionate about making high-quality dermatologic care and medical weight loss accessible through convenient telehealth and personalized, patient-centered treatment.